Endocrine Abstracts

Various criteria have been proposed to diagnose and treat gestational diabetes due to uncertainties about the influence of mild degrees of maternal glucose intolerance on pregnancy outcomes. We used receiver operating characteristics (ROC) curve analysis to correlate macrosomia (more than or equal to 4000g) with varying thresholds for the 2 hour 75 gm oral glucose tolerance test (OGTT) results in pregnant women screened at our hospital from 1998-2001.Wom...

Management of Thyrotoxicosis in a Non-compliant Pregnant WomanA 23-year-old woman with Grave's disease presented to thyroid clinic 29 weeks into her first pregnancy having recently moved into the area. She had failed to attend hospital thyroid clinics elsewhere and frequently changed her address.Despite propylthiouracil 300 mg daily she had marked tremor, tachycardia 100 bpm, ophthalmopathy, and a large smooth goitre. TSH <0.0...

Chronic fatigue syndrome (CFS) is a common and disabling problem; although most likely of biopsychosocial origin, the nature of the pathophysiological components remains unclear. Most studied has been the hypothalamic-pituitary-adrenal (HPA) axis; although the quality of many studies is poor, the overall balance of evidence points to reduced cortisol output in at least some patients, with some evidence that this is linked to symptom production or persistence. However, there is...